5-methyldihydrouridine

Common name:
5-methyldihydrouridine
Symbol:
m5D
CA index name:
Hydrouracil, 5-methyl-1-b-D-ribofuranosyl-
CA registry numbers:
ribonucleoside 23067-10-9
base 696-04-8
elemental composition:
C10H16N2O6
nucleoside mass:
260.25
rna-image
Source type phylogenetic source
archaea bacteria eukarya
chromosomal RNA [1]

Structure: [1]


Synthesis: [2]


Comment: This RNA is reported as a chromatin-associated 3.2-3.8S species, with an unusual concentration of dihydropyrimidine nucleosides, but its occurrence as a separate class of RNA remains controversial. For review, see [3]. Characterization of this nucleoside, not otherwise reported in RNA, was based on detection of 2-amino-isobutyric acid following treatment with alkali [1]. Direct comparison with the authentic nucleoside was not made.


References:


  1. Jacobson, R.A. and Bonner, J. (1968) Biochem. Biophys. Res. Commun., 33, 716-720.
  2. Cline, R.E., Fink, R.M. and Fink, K. (1959) J. Am. Chem. Soc., 81, 2521-2527.
  3. Naora, H. (1977) In Stewart, P.R. and Letham, D.S. (eds.) The Ribonucleic Acids. Springer-Verlag, Berlin, pp. 43-80.