3-methyluridine

Common name:
3-methyluridine
Symbol:
m3U
CA index name:
Uridine, 3-methyl-
CA registry numbers:
ribonucleoside 2140-69-4
base 608-34-4
elemental composition:
C10H14N2O6
nucleoside mass:
258.23
rna-image
Source type phylogenetic source
archaea bacteria eukarya
rRNA 23S [1] 16, 23S [2] 18, 28S [4]25, 28S [5]
Comment: In a recent examination of E. coli 23S rRNA, m3U was not detected [3].

Structure: [4]


Synthesis: [6]


Comment: Verification that the early report of m3U synthesis [5] was correct was made much later [7]. Although this nucleoside was reported present in both 18S and 28S rRNA from HeLa cells [4], later studies showed it to be confined to the 28S rRNA [5].


References:


  1. Noon, K.R., Bruenger, E. and McCloskey, J.A. (1998) J. Bacteriol., 180, 2883-2888.
  2. Johnson, J.D. and Horowitz, J. (1971) Biochim. Biophys. Acta, 247, 262-279.
  3. Kowalak, J.A., Pomerantz, S.C., Crain, P.F. and McCloskey, J.A. (1993) Nucleic Acids Res. 21, 4577-4585.
  4. Iwanami, Y. and Brown, G. (1968) Arch. Biochem. Biophys., 126, 8-15.
  5. Klagsbrun, M. (1973) J. Biol. Chem., 248, 2612-2620.
  6. Levene, P.A. and Tipson, R.S. (1934) J. Biol. Chem., 104, 385-393.
  7. Miles, H.T. (1956) Biochim. Biophys. Acta, 22, 247-253.