5-methylaminomethyl-2-selenouridine

Common name:
5-methylaminomethyl-2-selenouridine
Symbol:
mnm5se2U
CA index name:
Uridine, 5-[(methylamino)methyl]-2-seleno-
CA registry numbers:
ribonucleoside 89314-80-7
base 114482-38-1
elemental composition:
C11H17N3O5Se
nucleoside mass:
350.23
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + +

Structure: [1]


Synthesis: [1]


Comment: Earlier reports of se4U in RNA cited in [1] were discounted, as discussed in [1]. Although only one selenonucleoside, mnm5se2U, has been structurally characterized, it is likely that others exist but have not been detected due to oxidation, for example, in eukaryotic tRNA [2].


References:


  1. Wittwer, A.J., Tsai, L., Ching, W.-M. and Stadtman, T.C. (1984) Biochemistry, 23, 4650-4655.
  2. Ching, W.-M. (1984) Proc. Natl. Acad. Sci. USA, 81, 3010-3013.