2'-O-methyluridine

Common name:
2'-O-methyluridine
Symbol:
Um
CA index name:
Uridine, 2'-O-methyl-
CA registry numbers:
ribonucleoside 2140-76-3
base 66-22-8
elemental composition:
C10H14N2O6
nucleoside mass:
258.23
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 16, 23S [1] 23S [2] [3]5.8S [4]17mt [5]17, 25S [6]18+28S [7]
mRNA [8]
snRNA [9]

Structure: [2], [10]


Synthesis: [11]


Comment: First characterized as an O-2' or O-3' methyl derivative [3], and subsequently shown to be O-2' [10].


References:


  1. Noon, K.R., Bruenger, E. and McCloskey, J.A. (1998) J. Bacteriol., 180, 2883-2888.
  2. Nichols, J.L. and Lane, B.G. (1966) Can. J. Biochem., 44, 1633-1645.
  3. Jones, J.W. and Robins, R.K. (1963) J. Am. Chem. Soc., 85, 193-201.
  4. Rubin, G.M. (1974) J. Biol. Chem., 248, 3860-3875.
  5. Dubin, D.T. and Taylor, R.H. (1978) J. Mol. Biol., 121, 523-540.
  6. Klagsbrun, M. (1973) J. Biol. Chem., 248, 2612-2620.
  7. Singh, H. and Lane, B.G. (1964) Can. J. Biochem., 42, 1011-1021.
  8. Desrosiers, R., Friderici, K. and Rottman, F. (1974) Proc. Natl. Acad. Sci. USA, 71, 3971-3975.
  9. Busch, H., Ro-Choi, T.S., Prestayko, A.W., Shibata, H., Crooke, S.T., El-Khatib, S.M., Choi, Y.C. and Mauritzen, C.M. (1971) Perspect. Biol. Med., 15, 117-139.
  10. Hall, R.H. (1963) Biochim. Biophys. Acta, 68, 278-283.
  11. Furukawa, Y., Kobayashi, K., Kanai, Y. and Honjo, M. (1965) Chem. Pharm. Bull., 13, 1273-1278.