5-methyluridine

Common name:
5-methyluridine
Symbol:
m5U
CA index name:
Uridine, 5-methyl-
CA registry numbers:
ribonucleoside 1463-10-1
base 65-71-4
elemental composition:
C10H14N2O6
nucleoside mass:
258.23
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 16, 23S [1]23S [2]
tmRNA [3]

Structure: [4]


Synthesis: [5]


Comment: Alternate commonly used symbol is T. Other common names are thymine riboside and ribosylthymine. Occurrence is rare in archaeal tRNA. Enzymatic synthesis was reported in [6], which preceded the first report of chemical synthesis [5].


References:


  1. Hayashi, Y., Osawa, S. and Miura, K. (1966) Biochim. Biophys. Acta, 129, 519-531.
  2. Fellner, P. (1969) Eur. J. Biochem., 11, 12-27.
  3. Felden, B., Hanawa, K., Atkins, J.F., Himeno, H., Muto, A., Gesteland, R.F., McCloskey, J.A. and Crain, P.F. (1998) EMBO J., 17, 3188-3196.
  4. Littlefield, J.W. and Dunn, D.B. (1958) Biochem. J., 70, 642-651.
  5. Fox, J.J., Yung, N., Davoll, J. and Brown, G.B. (1956) J. Am. Chem. Soc., 78, 2117-2122.
  6. Lampen, J.O. (1952) In McElroy, W.D. and Glass, B. (eds.) Phosphorus Metabolites. The Johns Hopkins Press, Baltimore, Vol. II, pp. 368.