archaeosine

Common name:
archaeosine
Symbol:
G+
CA index name:
1H-Pyrrolo[2,3-d]pyrimidine-5-carboximidamide, 2-amino-4,7-dihydro-4-oxo- 7-b-D-ribofuranosyl-
CA registry numbers:
ribonucleoside 148608-52-0
base 160814-20-0
elemental composition:
C12H16N6O5
nucleoside mass:
324.3
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA +

Structure: [1]


Synthesis: [1]


Comment: Symbol G+ was assigned based on the positive charge carried by the nucleoside, as noted at the time of its original discovery [2]; G* or G*-15 have been used but are no longer preferred. Alternate name is 7-formamidino-7-deazaguanosine. The Chemical Abstracts Index Name is based on nomenclature for the 4(1H)-quinazolinone ring system. Chemical synthesis of the corresponding base is reported in [3]. The bacterial nucleoside preQ0 is a biosynthetic precursor of G+ [4].


References:


  1. Gregson, J.M., Crain, P.F., Edmonds, C.G., Gupta, R., Hashizume, T., Phillipson, D.W. and McCloskey, J.A. (1993) J. Biol. Chem. 268, 10076-10086.
  2. Kilpatrick, M.W. and Walker, R.T. (1982) Zentralbl. Bakteriol. Mikrobiol. Hyg. 1 Abt. Orig. C 3, 79-89.
  3. Hashizume, T. and McCloskey, J.A. (1994) Nucleic Acids Res. Symp. Ser. 31, 137-138.
  4. Watanabe, M., Matsuo, M., Tanaka, S., Akimoto, H., Asahi, S., Nishimura, S., Katze, J.R., Hashizume, T., Crain, P.F., McCloskey, J.A. and Okada, N. (1997) J. Biol. Chem. 272, 20146-20151.