7-cyano-7-deazaguanosine

Common name:
7-cyano-7-deazaguanosine
Symbol:
preQ0
CA index name:
1H-Pyrrolo[2,3-d]pyrimidin-5-carbonitrile, 2-amino-4,7-dihydro-4-oxo- 7-b-D-ribofuranosyl-
CA registry numbers:
ribonucleoside 61210-21-7
base 69205-79-4
elemental composition:
C12H13N5O5
nucleoside mass:
307.26
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA +

Structure: [1]


Synthesis: [2]


Comment: preQ0 and preQ1 are undermodified Q nucleosides isolated from methyl-deficient mutant E. coli tRNA.


References:


  1. Noguchi, S., Yamaizumi, Z., Ohgi, T., Goto, T., Nishimura, Y., Hirota, Y. and Nishimura, S. (1978) Nucleic Acids Res., 5, 4215-4223.
  2. Cheng, C.S., Hinshaw, B.C., Panzica, R.P. and Townsend, L.B. (1976) J. Am. Chem. Soc., 98, 7870-7872.