2'-O-methyladenosine

Common name:
2'-O-methyladenosine
Symbol:
Am
CA index name:
Adenosine, 2'-O-methyl-
CA registry numbers:
ribonucleoside 2140-79-6
base 73-24-5
elemental composition:
C11H15N5O4
nucleoside mass:
281.27
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 16, 23S [1] 16S [10] [2]5.8S [3]17, 26S [4]18+28S [5]
mRNA [6]
snRNA [7]
Comment: Am is also found in U3 RNA from the nucleolus.

Structure: [2], [8]


Synthesis: [9]


Comment: Occurrence is rare in eukaryotes. First characterized as an O-2' or O-3' methyl derivative [8], and subsequently shown to be O-2' [9].


References:


  1. Noon, K.R., Bruenger, E. and McCloskey, J.A. (1998) J. Bacteriol., 180, 2883-2888.
  2. Smith, J.D. and Dunn, D.B. (1959) Biochim. Biophys. Acta, 31, 573-575.
  3. Lau, R.Y., Kennedy, T.D. and Lane, B.G. (1974) Can. J. Biochem., 52, 1110-1122.
  4. Cecchini, J.P. and Miassod, R. (1979) Eur. J. Biochem., 98, 203-214.
  5. Singh, H. and Lane, B.G. (1964) Can. J. Biochem., 42, 1011-1021.
  6. Desrosiers, R., Friderici, K. and Rottman, F. (1974) Proc. Natl. Acad. Sci. USA, 71, 3971-3975.
  7. Busch, H., Ro-Choi, T.S., Prestayko, A.W., Shibata, H., Crooke, S.T., El-Khatib, S.M., Choi, Y.C. and Mauritzen, C.M. (1971) Perspect. Biol. Med., 15, 117-139.
  8. Hall, R.H. (1963) Biochim. Biophys. Acta, 68, 278-283.
  9. Broom, A.D. and Robins, R.K. (1965) J. Am. Chem. Soc., 87, 1145-1146.
  10. Guymon, R., Pomerantz, S.C., Crain, P.F. and McCloskey, J.A. (2006) Biochemistry, 45, 4888-4899.