2'-O-methylguanosine

Common name:
2'-O-methylguanosine
Symbol:
Gm
CA index name:
Guanosine, 2'-O-methyl-
CA registry numbers:
ribonucleoside 2140-71-8
base 73-40-5
elemental composition:
C11H15N5O5
nucleoside mass:
297.27
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 16, 23S [1] 23S [2] [3]5.8S [4, 5, 6]18+28S [7]
mRNA [8]
snRNA [9]

Structure: [3], [10], [11]


Synthesis: [12]


Comment: First characterized as an O-2' or O-3' methyl derivative [10], and subsequently shown to be O-2' [11].


References:


  1. Noon, K.R., Bruenger, E. and McCloskey, J.A. (1998) J. Bacteriol., 180, 2883-2888.
  2. Nichols, J.L. and Lane, B.G. (1966) Can. J. Biochem., 44, 1633-1645.
  3. Morisawa, S. and Chargaff, E. (1963) Biochim. Biophys. Acta, 68, 147-149.
  4. Lau, R.Y., Kennedy, T.D. and Lane, B.G. (1974) Can. J. Biochem., 52, 1110-1122.
  5. Maden, B.E.H. and Robertson, J.S. (1974) J. Mol. Biol., 87, 227-235.
  6. Nazar, R., Sitz, T.O. and Busch, H. (1974) FEBS Lett., 45, 206-212.
  7. Singh, H. and Lane, B.G. (1964) Can. J. Biochem., 42, 1011-1021.
  8. Desrosiers, R., Friderici, K. and Rottman, F. (1974) Proc. Natl. Acad. Sci. USA, 71, 3971-3975.
  9. Busch, H., Ro-Choi, T.S., Prestayko, A.W., Shibata, H., Crooke, S.T., El-Khatib, S.M., Choi, Y.C. and Mauritzen, C.M. (1971) Perspect. Biol. Med., 15, 117-139.
  10. Smith, J.D. and Dunn, D.B. (1959) Biochim. Biophys. Acta, 31, 573-575.
  11. Hall, R.H. (1963) Biochim. Biophys. Acta, 68, 278-283.
  12. Khwaja, T.A. and Robins, R.K. (1966) J. Am. Chem. Soc., 88, 3640-3643.