7-methylguanosine

Common name:
7-methylguanosine
Symbol:
m7G
CA index name:
1H-Purinium, 2-amino-6,9-dihydroxy-7-methyl-6-oxo- 9-b-D-ribofuranosyl-
CA registry numbers:
ribonucleoside 20244-86-4
base 578-76-7
elemental composition:
C11H15N5O5
nucleoside mass:
297.27
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 16S [1] [2] 17, 18S [3]17, 26S [4]18, 28S [5]
Comment: Although this nucleoside was reported in both 18S and 28S rRNA from HeLa cells [5],
later studies showed it to be confined to the 18S rRNA [6].
mRNA [7]
Comment: This 5'-cap nucleoside is joined to the RNA through a unique triphosphate bridge [Gp(5'-5')ppN...]

Structure: [8]


Synthesis: [9]


Comment: First characterized as the base [8] and later as the monoribonucleotide [10].


References:


  1. Zueva, V.S., Mankin, A.S., Bogdanov, A.A., Thurlow, D.L. and Zimmermann, R.A. (1985) FEBS Lett., 188, 233-238.
  2. Isaksson, L.A. and Phillips, J.H. (1968) Biochim. Biophys. Acta, 115, 63-71.
  3. Thomas, G., Gordon, J. and Rogg, H. (1978) J. Biol. Chem., 253, 1101-1105.
  4. Cecchini, J.P. and Miassod, R. (1979) Eur. J. Biochem., 98, 203-214.
  5. Iwanami, Y. and Brown, G. (1968) Arch. Biochem. Biophys., 126, 8-15.
  6. Maden, B.E.H. and Salim, M. (1974) J. Mol. Biol., 88, 133-164.
  7. Rottman, F., Shatkin, A.J. and Perry, R.P. (1974) Cell, 3, 197-199.
  8. Dunn, D.B. (1961) Biochim. Biophys. Acta, 46, 198-200.
  9. Haines, J.A., Reese, C.B. and Todd, L. (1962) J. Chem. Soc., 5281-5287.
  10. Dunn, D.B. (1963) Biochem. J., 86, 14P-15P.