2'-O-methylcytidine

Common name:
2'-O-methylcytidine
Symbol:
Cm
CA index name:
Cytidine, 2'-O-methyl-
CA registry numbers:
ribonucleoside 2140-72-9
base 71-30-7
elemental composition:
C10H15N3O5
nucleoside mass:
257.25
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA 5S [1]16, 23S [2] 16S [13]23S [3] [4]5.8S [5]18, 28S [6]17S [7]
mRNA [8]
snRNA [9]

Structure: [10], [11]


Synthesis: [12]


Comment: Cm was first characterized as an O-2' or O-3' methyl derivative [10], and subsequently shown to be O-2' [11].


References:


  1. Bruenger, E., Kowalak, J.A., Kuchino, Y., McCloskey, J.A., Stetter, K.O. and Crain, P.F. (1993) FASEB J., 7, 196-200.
  2. Noon, K.R., Bruenger, E. and McCloskey, J.A. (1998) J. Bacteriol., 180, 2883-2888.
  3. Nichols, J.L. and Lane, B.G. (1966) Can. J. Biochem., 44, 1633-1645.
  4. Morisawa, S. and Chargaff, E. (1963) Biochim. Biophys. Acta, 68, 147-149.
  5. MacKay, R.M. and Doolittle, W.F. (1981) Nucleic Acids Res., 9, 3321-3334.
  6. Iwanami, Y. and Brown, G. (1968) Arch. Biochem. Biophys., 126, 8-15.
  7. Thomas, G., Gordon, J. and Rogg, H. (1978) J. Biol. Chem., 253, 1101-1105.
  8. Desrosiers, R., Friderici, K. and Rottman, F. (1974) Proc. Natl. Acad. Sci. USA, 71, 3971-3975.
  9. Shibata, H., Ro-Choi, T.S., Reddy, R., Choi, Y.C., Henning, D. and Busch, H. (1975) J. Biol. Chem., 250, 3909-3920.
  10. Smith, J.D. and Dunn, D.B. (1959) Biochim. Biophys. Acta, 31, 573-575.
  11. Biswas, B.B. and Myers, J. (1960) Nature, 186, 238-239.
  12. Furukawa, Y., Kobayashi, K., Kanai, Y. and Honjo, M. (1965) Chem. Pharm. Bull., 13, 1273-1278.
  13. Guymon, R., Pomerantz, S.C., Ison, J.N., Crain, P.F. and McCloskey, J.A. (2007) RNA, 13, 396-403.