2-methyladenosine

Common name:
2-methyladenosine
Symbol:
m2A
CA index name:
Adenosine, 2-methyl-
CA registry numbers:
ribonucleoside 16526-56-0
base 1445-08-5
elemental composition:
C11H15N5O4
nucleoside mass:
281.27
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + +
rRNA 23S [1]23S [2]

Structure: [3]


Synthesis: [4]


Comment: Although ref [1] reports m2A to be in a mixture of SSU and LSU subunits, various more recent studies have shown that m2A is not present in the bacterial SSU (see SSU database) but is in the LSU [5].


References:


  1. Starr, J.L. and Fefferman, R. (1964) J. Biol. Chem., 239, 3457-3461.
  2. Dubin, D.T. and G├╝nalp, A. (1967) Biochim. Biophys. Acta, 134, 106-123.
  3. Littlefield, J.W. and Dunn, D.B. (1958) Nature, 181, 254-255.
  4. Davoll, J. and Lowy, B.A. (1952) J. Am. Chem. Soc., 74, 1563-1566.
  5. Kowalak, J.A., Pomerantz, S.C., Crain, P.F., and McCloskey, J.A. (1993) Nucleic Acids Res. 21, 4577-4585.