1-methyladenosine

Common name:
1-methyladenosine
Symbol:
m1A
CA index name:
Adenosine, 1-methyl-
CA registry numbers:
ribonucleoside 15763-06-1
base 5142-22-3
elemental composition:
C11H15N5O4
nucleoside mass:
281.27
rna-image
Source type phylogenetic source
archaea bacteria eukarya
tRNA + + +
rRNA [1] 16+25S [2]18, 28S [3]26, 28S [4]
Comment: This nucleoside is not reported in the sequence of 18S rRNA from HeLa cells [5].

Structure: [6]


Synthesis: [7]


Comment: First characterized as the base [6] and later as the monoribonucleotide [8].


References:


  1. Srivastava, R. and Gopinathan, K.P. (1987) Biochem. Int., 15, 1179-1188.
  2. Isaksson, L.A. and Phillips, J.H. (1968) Biochim. Biophys. Acta, 115, 63-71.
  3. Iwanami, Y. and Brown, G. (1968) Arch. Biochem. Biophys., 126, 8-15.
  4. Klagsbrun, M. (1973) J. Biol. Chem., 248, 2612-2620.
  5. Maden, B.E.H. and Salim, M. (1974) J. Mol. Biol., 88, 133-164.
  6. Dunn, D.B. (1961) Biochim. Biophys. Acta, 46, 198-200.
  7. Jones, J.W. and Robins, R.K. (1963) J. Am. Chem. Soc., 85, 193-201.
  8. Dunn, D.B. (1963) Biochem. J., 86, 14P-15P.